5-Hydroxy-1-methylpyrazole CAS 33641-15-5
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5-Hydroxy-1-methylpyrazole CAS 33641-15-5

5-Hydroxy-1-methylpyrazole CAS 33641-15-5

MF: C4H6N2O
MW: 98.1
CAS: 33641-15-5

Description

About 5-Hydroxy-1-methylpyrazole CAS 33641-15-5

Introduction
5-Hydroxy-1-methylpyrazole (molecular formula C₄H₆N₂O, molar mass 98.10 g/mol) is a white crystalline solid with a pyrazole core featuring a hydroxyl group at the 5-position and a methyl substituent at the 1-position. This structural design 赋予独特 reactivity,making it a critical intermediate in agrochemical and pharmaceutical synthesis.

 

Chemical Properties

 

Appearance: White crystalline powder

Melting Point: 160–162°C

Solubility: Moderately soluble in water (1.2 g/L at 25°C); highly soluble in ethanol, methanol, and acetone.

Stability: Stable under normal conditions; decomposes in strong acidic/basic environments.

 

Advantages

1.

Mode of Action:

Serves as a key intermediate for synthesizing ALS-inhibiting herbicides (e.g., sulfonylureas and triazolopyrimidines).

Its hydroxyl group participates in nucleophilic substitutions to form herbicidal active ingredients targeting annual weeds.

2.

Derivatives:

Precursors for fungicides like pyraclostrobin and insecticides like fipronil analogs.

 

Synthesis Methods

 

 
Synthesis Methods of 5-Hydroxy-1-methylpyrazole CAS 33641-15-5
 

 

 

Oxidation of 1-Methylpyrazole-5-carboxylic Acid:

Catalytic oxidation using potassium permanganate:
C₅H₆N₂O₂ + [O] → C₄H₆N₂O + CO₂ + H₂O

Hydrolysis of 1-Methylpyrazole-5-nitrile:

Acidic hydrolysis converts nitrile to hydroxyl group:
C₅H₅N₃ + 2H₂O → C₄H₆N₂O + NH₃

 

Related Product Introduction

 

Shandong sparrow chemical co.,ltd 
 

Our company mainly produces Insecticides, Herbicides, and Fungicides, catalysts and fine chemicals.
Regarding phthalaldehyde, the company now has a professional and stable production technology and strength. At the same time, the company also produces other related products, such as aromatic aldehyde series products, aromatic acid series products, aromatic ketone series products.

 
OPA plant

 

 

How to start order?

Contact information:

Mr. Jack Yang

Phone: +8618615266189

Email: export006@sparrowchemical.com

Wechat:+8618615266189

WhatsApp:+8618615266189

OPA supplier

 

 

 

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