Description
About 5-Hydroxy-1-methylpyrazole CAS 33641-15-5
Introduction
5-Hydroxy-1-methylpyrazole (molecular formula C₄H₆N₂O, molar mass 98.10 g/mol) is a white crystalline solid with a pyrazole core featuring a hydroxyl group at the 5-position and a methyl substituent at the 1-position. This structural design 赋予独特 reactivity,making it a critical intermediate in agrochemical and pharmaceutical synthesis.
Chemical Properties
Appearance: White crystalline powder
Melting Point: 160–162°C
Solubility: Moderately soluble in water (1.2 g/L at 25°C); highly soluble in ethanol, methanol, and acetone.
Stability: Stable under normal conditions; decomposes in strong acidic/basic environments.
Advantages
1.
Mode of Action:
Serves as a key intermediate for synthesizing ALS-inhibiting herbicides (e.g., sulfonylureas and triazolopyrimidines).
Its hydroxyl group participates in nucleophilic substitutions to form herbicidal active ingredients targeting annual weeds.
2.
Derivatives:
Precursors for fungicides like pyraclostrobin and insecticides like fipronil analogs.
Synthesis Methods
Synthesis Methods of 5-Hydroxy-1-methylpyrazole CAS 33641-15-5
Oxidation of 1-Methylpyrazole-5-carboxylic Acid:
Catalytic oxidation using potassium permanganate:
C₅H₆N₂O₂ + [O] → C₄H₆N₂O + CO₂ + H₂O
Hydrolysis of 1-Methylpyrazole-5-nitrile:
Acidic hydrolysis converts nitrile to hydroxyl group:
C₅H₅N₃ + 2H₂O → C₄H₆N₂O + NH₃
Related Product Introduction
Our company mainly produces Insecticides, Herbicides, and Fungicides, catalysts and fine chemicals.
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Contact information:
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Phone: +8618615266189
Email: export006@sparrowchemical.com
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