2,5-Dimethylphenylacetyl Chloride CAS 55312-97-5
MF： C10H11ClO
MW： 182.65
CAS： 55312-97-5
Description
About 2,5-Dimethylphenylacetyl chloride CAS 55312-97-5
2,5-Dimethylphenylacetyl Chloride (CAS 55312-97-5): A Specialized Spirotetramat intermediate.
Introduction
2,5-Dimethylphenylacetyl chloride (molecular formula C₁₀H₁₁ClO, molar mass 182.65 g/mol) is a colorless to pale yellow liquid with a pungent odor. As a substituted phenylacetyl chloride, its structure contains two methyl groups at the 2- and 5-positions of the benzene ring, reactivity for advanced organic synthesis.
Product Chemical Properties
Appearance: Clear liquid with a sharp, acrid smell.
Melting Point: -25°C (estimated)
Boiling Point: 245–247°C (at 760 mmHg)
Solubility: Insoluble in water; miscible with dichloromethane, ethyl acetate, and chloroform.
Stability: Hydrolyzes rapidly in water/ethanol, releasing HCl gas. Reacts violently with bases and nucleophiles.
Synthesis Methods
Phosgenation of 2,5-Dimethylphenylacetic Acid:
React 2,5-dimethylphenylacetic acid with phosgene (COCl₂) under reflux:
C₆H₃(CH₃)₂CH₂COOH + COCl₂ → C₆H₃(CH₃)₂CH₂COCl + CO₂ + HCl
Thionyl Chloride Method:
Treat the acid with thionyl chloride (SOCl₂) in pyridine:
C₆H₃(CH₃)₂CH₂COOH + SOCl₂ → C₆H₃(CH₃)₂CH₂COCl + SO₂ + HCl
Purification involves vacuum distillation to remove byproducts.
Products Usages
usages of 2,5-Dimethylphenylacetyl chloride CAS 55312-97-5
Pharmaceuticals: Key intermediate for synthesizing antipsychotics (e.g., atypical neuroleptics) and anti-inflammatory drugs.
Agrochemicals: Precursor for insecticides targeting Coleoptera pests.
Materials Science: Used in polymer modification to introduce functional groups.
Spirotetramat intermediate.
Related Products:
China: Export compliance with HG/T 5813-2021 (industrial grade specifications).
EU: Classified as Corrosive (C) under CLP Regulation (EC) No 1272/2008. MRLs for residues in food are governed by Regulation (EC) No 396/2005.
Global Trade: Adhere to UN GHS hazard statements (H314, H335) and SDS requirements.
UN Number: UN 2277
Class: 8 (Corrosive Substance)
Packaging:
Primary: Sealed stainless steel drums (200 kg net) or polyethylene-lined drums (25 kg net).
Secondary: Palletized with absorbent materials for spill containment.
Handling: Store in cool, dry areas away from moisture and incompatible substances (amines, alcohols).
Products Shipment
Shipment
01
International express
02
By sea
03
By air
04
By railway
How to start order?
Contact information:
Mr. Jack Yang
Phone: +8618615266189
Email: export006@sparrowchemical.com
Wechat:+8618615266189
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