4-bromochlorobenzene CAS 106-39-8

1. Capacity:

    Yearly 400 tons, in stock.

2. Properties:

    The 4-Bromochlorobenzene is white to yellow powder to crystals.

    Almost insoluble in water. Soluble in organic solvents such as ethanol, ether, benzene, and chloroform.

3. Usages:

    Pharmaceutical chemical synthesis intermediates (especially the preparation of chemical products).

 

 

4-Bromochlorobenzene details

Basic information

Name：	4-Bromochlorobenzene
MF：	C6H4BrCl
MW：	191.45
CAS：	106-39-8

Appearance

White to yellow powder to crystals

 

Packages

1kg/5kg/25kg/bag/drum

(Can offer samples for your need)

shippment

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Chemical Properties:

Specification Sheet:

Unique electronic effects
Halogen synergistic effect:

The molecule of 4-bromochlorobenzene contains both bromine and chlorine atoms, bromine atoms have a strong electron-donating effect (+I effect), and chlorine atoms have an electron-withdrawing effect (-I effect). This unique electron distribution allows 4-bromochlorobenzene to exhibit special reactivity in chemical reactions, especially in electrophilic substitution reactions.
Positioning effect:

The para substitution of bromine and chlorine atoms in the benzene ring makes the electron density distribution in the benzene ring more complex and suitable for the synthesis of organic compounds with specific structures.
Chemical stability
High thermal stability and chemical inertness:

4-bromochlorobenzene has high chemical stability at room temperature and is not easy to decompose or produce side reactions. This stability allows it to remain structurally intact even in high temperature reactions or harsh conditions.
Oxidation resistance:

Compared with monohalogenated benzene, 4-bromochlorobenzene has stronger resistance to oxidants and is suitable for oxidation reaction systems.
Physical properties
Higher boiling and melting points:

4-bromochlorobenzene has higher boiling points (196-198 °C) and melting points (68-70 °C) and is suitable for reaction conditions that require higher temperatures.
High density:

4-bromochlorobenzene has a higher density (1.63 g/cm³) than many mono-halogenated benzenes, which makes it easier to achieve separation by density differences during isolation and purification.

Preparation of 2-(4-chlorophenyl) nitrobenzene

2-(4-chlorophenyl) nitrobenzene is an intermediate for the preparation of pectinylamine, which is a new fungicide with the characteristics of safety, eco-friendliness and low toxicity to crops.

In recent studies, p-chlorobromobenzene and o-chloronitrobenzene were used as raw materials to catalyze the coupling reaction in benzene, ether or tetrahydrofuran solvents with Ni and PPh3 as catalysts under the protection of inert gas. This method has the advantages of fast reaction speed, small amount of catalyst, short reaction time, and the total yield can reach more than 90%, which is suitable for industrial production.

Preparation of important intermediates of betostine

Betostin besylate is a histamine H-1 receptor antagonist. It has the effect of platelet activating factor antagonist, anti-allergic. It can quickly and effectively inhibit the main symptoms of allergic rhinitis, and has broad clinical prospects. 4-[4-[(4-chlorophenyl)(2-pyridyl) methoxy] piperidine-1-yl] ethyl butyrate (an important intermediate of Betostine) was prepared from 2-pyridyl formaldehyde, p-chlorobenzene format reagent and 4-bromo-1-piperidine-ethyl butyrate as raw materials by "one-pot" method. This method overcomes the disadvantages of multi-step reaction, and has the advantages of simple operation, short cycle, less equipment investment, high yield, and good application prospect.

Preparation of 4-chlorophenyl cyclopropyl methyl ketone

4-chlorophenyl cyclopropyl methyl ketone is an important raw material for the synthesis of 1-(4-chlorophenyl) -2-cyclopropyl 1-acetone, a key intermediate of the fungicide cycloazolol.
The preparation process is divided into two steps: (1) adding magnesium metal to ether or tetrahydrofuran, adding p-chlorobromobenzene solution, heating up to reflux temperature for 1~2 hours to produce Grindler reagent; ② The reaction system was cooled to -5~0℃, cyclopropyl acetonitrile solution was added, and temperature was raised to reflux temperature for 1~2 hours to generate 4-chlorophenyl cyclopropyl methyl ketone, and the finished product was obtained after post-treatment.
 

Shandong sparrow chemical co.,ltd 

 

Shandong Sparrow Chemical was established in 2007, focusing on the research and development, production and sales of fine chemicals and pharmaceutical intermediates. The factory has advanced production equipment and perfect quality management system, the main products include halogenated aromatic hydrocarbons, organic acids, catalysts, etc., widely used in medicine, pesticides, materials science and other fields.

We are committed to providing our customers with high-quality chemicals and customized solutions, adhere to green production, and promote sustainable development.

 

 

Related Products:

Product	CAS Number
4-Chlorobromobenzene	106-39-8
4-Bromoiodobenzene	589-87-7
4-Chloroiodobenzene	637-87-6
4-Bromofluorobenzene	460-00-4
4-Chlorofluorobenzene	352-33-0

4-Bromobenzoic Acid	586-76-5
4-Chlorobenzoic Acid	74-11-3
4-Bromobenzaldehyde	1122-91-4

 

 

 

Products Shipment

Shipment

 

 

01

International express

 

02

By sea

 

03

By air

 

04

By railway

 

How to start order?

Contact information:

Melanie Yin

Phone: +8615662727073

Email: export012@sparrowchemical.com

WhatsApp:+8618363408350

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