4-aminobiphenyl CAS 92-67-1

● Determination by colorimetric method

4-amino-biphenyl can react with sulfate under specific conditions to produce colored substances. For example, in acidic media, 4-amino-biphenyl undergoes a series of chemical reactions with sulfate and other reagents, and finally forms a colored complex with an absorption peak at a specific wavelength. By measuring the absorbance of the complex at a specific wavelength and using the Lambert-Beer law, it is possible to establish a curve of the relationship between the absorbance and the sulfate concentration, so as to realize the quantitative determination of the sulfate content in the sample.

● Principle as a chromogen

The amino group (-NH₂) in the molecular structure of 4-aminobiphenyl has a certain reaction activity. In the system of sulfate determination, it can react with sulfate and related reagents, change its electron cloud structure, and then produce color change.

● Synthetic azo dyes

4-aminobiphenyl is an important raw material for the synthesis of azo dyes. In the synthesis process, the amino group (-NH₂) of 4-aminobiphenyl is transformed into diazonium salt by diazotization. Diazonium salt is highly reactive and can react with various phenolic and arylamine compounds to form dye molecules containing azo groups (-N=N-).

● To give the dye special properties

The dyes synthesized by 4-aminobiphenyl have good light and wash resistance. This is because the biphenyl structure of 4-amino-biphenyl provides a large conjugation system for the dye molecules and enhances the stability of the molecules. The conjugated system can absorb light energy, reduce the decomposition of dye molecules caused by light, and thus improve the light resistance of the dye. At the same time, its structure also makes the bond

● Research on the mechanism of cancer

As a typical chemical carcinogen, 4-aminobiphenyls (4-AB) can induce cancer in experimental animals to observe the process of cancer. In animal experiments, exposure of experimental animals (such as rats and mice) to 4-aminobiphenyls can induce tumors in organs such as urinary system and liver.

● Cancer risk assessment

In the field of environmental and occupational health, 4-aminobiphenyls can be used to assess the carcinogenic risk of chemicals. By studying the changes of biomarkers, such as DNA adducts formation and gene mutation frequency, after exposure to 4-aminobiphenyl in humans or animals, a dose-response relationship model was established, and then the possible carcinogenic risks of other similar chemicals were speculated.