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1-Adamantanamine Hydrochloride

1-Adamantanamine Hydrochloride

1-Adamantanamine Hydrochloride, also referred to as Amantadine Hydrochloride, is a high-purity crystalline compound with the molecular formula C10H17N·HCl. It features a unique adamantane framework coupled with an amine group, making it a versatile compound for applications in pharmaceuticals, chemical research, and materials science.

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Description

 
Company Profile
 

Shandong Sparrow Chemical Co., Ltd. was established in 2017, is a collection of organophosphine compounds, organophosphine precious metal catalysts and pharmaceutical intermediates research and development, production and customization. Adhering to the core values of "people-oriented, honest work, harmonious development", the company has always taken "creating value for customers, creating platforms for employees, creating wealth for society" as its mission, and strives to cooperate with all sectors of society to achieve healthy and long-term sustainable development of the company.

 

Why Choose Us
01/

Rich Experience
Since its establishment, the company own a young, high-quality and high-tech R & D, production and sales team, has a wealth of catalyst and ligand products research and development, production experience, can quickly develop and produce customer demand products, while can undertake difficult custom synthesis projects.

02/

Our service
Our professional team will provide customers with detailed product introduction and technical parameters before sales to answer customer questions. Sample testing will be provided to customers within a reasonable range upon customer request. Our professional quality management system and rich experience logistics team will ensure that the goods are delivered to customers on time. Our customer satisfaction is very important, high quality after-sales service will provide customers with timely, accurate, professional consultation and solutions to meet the various needs of customers, customer satisfaction is our greatest satisfaction.

03/

Production Market
Our business covers a wide range of regional markets around the world, with Asia, Europe and North America ‌as the core markets, relying on high-quality products and efficient service system, we continue to achieve remarkable results.

04/

Professional Team
Our professional research and development team and production team still can accept the CUSTOMIZED PRODUCT from gram to tons based on your needs.

 

 

What is 1-Adamantanamine hydrochloride?

 

 

1-Adamantanamine Hydrochloride, also referred to as Amantadine Hydrochloride, is a high-purity crystalline compound with the molecular formula C10H17N·HCl. It features a unique adamantane framework coupled with an amine group, making it a versatile compound for applications in pharmaceuticals, chemical research, and materials science.

 

Application of 1-Adamantanamine hydrochloride

 

 

Pharmaceutical Development
1-Adamantanamine Hydrochloride is widely utilized as an antiviral agent and a key ingredient in neurological drug formulations, particularly in treating Parkinson's disease and influenza.

Advanced Material Synthesis
Its amine functionality makes it valuable in creating amine-modified surfaces, polymers, and nanomaterials, contributing to innovative coatings and adhesives.

Organic Chemistry Research
The compound serves as a precursor in synthesizing derivatives with enhanced functionalities for diverse industrial and scientific applications.

 

Structure of 1-Adamantanamine hydrochloride

The compound consists of the rigid, cage-like adamantane backbone, enhancing structural stability. The primary amine (-NH2) group, combined with the hydrochloride salt form, ensures high solubility and consistent reactivity in aqueous environments.

Key Features

Exceptional Stability: Ideal for demanding applications.

Versatile Functionality: Compatible with various chemical reactions.

High Solubility: Suitable for both organic and aqueous systems.

 

 

1-Adamantanamine hydrochloride Responsiveness

 

 

The amine group of 1-Adamantanamine Hydrochloride exhibits high reactivity in various organic reactions, such as acylation, alkylation, and reductive amination. Its hydrochloride form enhances stability and compatibility, ensuring reliable performance even in rigorous processing conditions.

 

Our Factory

 

Shandong Sparrow Chemical Co., Ltd. was established in 2017, is a collection of organophosphine compounds, organophosphine precious metal catalysts and pharmaceutical intermediates research and development, production and customization.

 

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FAQ

Q: What is triphenylphosphine used for?

A: Triphenylphosphine is used in a variety of applications, including sensitizers, heat stabilisers, light stabilisers, antioxidants, flame retardants, antistatic agents, rubber antiozonants, and analytical reagents. Triphenylphosphine is used in the synthesis of vitamin D2, vitamin A, clindamycin, and other drugs.

Q: How do you get rid of triphenylphosphine?

A: If your product is stable and relatively-non polar, a good way of removing triphenylphosphine oxide is to concentrate the reaction mixture to a lower follow, suspend the residue in pentane (or hexane)/ether and filter over a silica plug.

Q: How do you quench triphenylphosphine?

A: Just ad some methyl iodide. The excess is volatile and your triphenylphosphine will be instantaneously converted into the phosphonium salt, insoluble in many solvents. It will also be retained if you filter through a short plug of neutral alumina.

Q: What is the byproduct of triphenylphosphine?

A: Ph3PO is a byproduct of many useful reactions in organic synthesis including the Wittig, Staudinger, and Mitsunobu reactions. It is also formed when PPh3Cl2 is employed to convert alcohols into alkyl chlorides: Ph3PCl2 + ROH → Ph3PO + HCl + RCl.

Q: What is the method of triphenylphosphine?

A: The preparation method comprises the following steps: reacting by adding potassium hydroxide or sodium hydroxide which is used as a solute to dimethyl sulfoxide which is used as a solvent, and reacting by inletting a phosphine gas to a reaction container; adding a chlorobenzene solution to the reaction container, and ...

Q: Why use triphenylphosphine?

A: Triphenylphosphine is used in pharmaceutical, organic synthesis, analyze and other industries. Also used as a whitening agent for dye technology, antioxidant for polymerization reactions and colour film development, stabilizer in the reaction of producing polyepoxide, and analytical reagent.

Q: Is triphenylphosphine flammable?

A: Triphenylphosphine is a flammable solid which slowly oxidizes in air to form triphenylphosphine oxide. It is insoluble in water. TRIPHENYL PHOSPHINE reacts vigorously with oxidizing materials.

Q: What is triphenylphosphine oxide used for?

A: TPPO has been used as an additive to aid co-crystallization of organic compounds. This is particularly useful if you have a poorly crystalline compound, or not very much compound to work with.

Q: How to get rid of triphenylphosphine?

A: If your product is stable and relatively-non polar, a good way of removing triphenylphosphine oxide (produced in Wittig, Mitsunobu, bromination, ond other reactions) is to concentrate the reaction mixture to a lower follow, suspend the residue in pentane (or hexane)/ether and filter over a silica plug.

Q: What is the hazard statement for Triphenylphosphine?

A: H372 Causes damage to organs (nervous system) through prolonged or repeated exposure. P260 Do not breathe dusts or mists. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/eye protection.

Q: How to remove trimethylphosphine oxide?

A: I have performed several reactions where the byproduct is triphenylphosphine oxide. The simplest way I have found to get rid of PPh3O is to dissolve the reaction mixture in ethanol, add 2 equivalents of zinc chloride (2 equivalents in comparison to PPh3) and stir for a couple of hours at room temperature.

Q: What is the role of triphenylphosphine?

A: Triphenylphosphine oxide is used as a catalyst, Lewis base, ligand for metals and starting material for the preparation of other phosphorus compounds. It is also used in epoxidations, Michael reactions and coupling reactions. It reacts with copper(II) halides and form coordination complexes of Copper(II).

Q: What is the solvent for triphenylphosphine?

A: In industry, triphenylphosphine is often purified by recrystallization from organic solvents, such as ethanol, benzene, and acetone. Thus, the solubility of triphenylphosphine in these organic solvents is of importance for the separation and purification process.

Q: How do you oxidize triphenylphosphine?

A: In the presence of Pd (II) catalyst, triphenylphosphine can be oxidized with molecular oxygen at room temperature under atmospheric pressure to form triphenylphosphine oxide. The rate of oxidation depended on the type of anionic ligand of palladium salt.

Q: Is triphenylphosphine hazardous?

A: Irritating to eyes, respiratory system and skin. May cause long-term adverse effects in the aquatic environment. Accidental ingestion of the material may be harmful; animal experiments indicate that ingestion of less than 150 gram may be fatal or may produce serious damage to the health of the individual.

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